To ensure safe and efficient operations,dedicated layout and handling equipment for automated container terminals are generally applied to isolate automated zones from non-automated areas spatially or temporally.It is difficult to achieve complete isolation between automated intelligent vehicle (AIV) and manually operated vehicle in the wharf and approach bridge areas in phase I container terminal renovation project in Luojing port area of Shanghai Port.By summarizing the layout principles of safety isolation facilities and safety management protocols for automated container terminals under different technical approaches,we organize a series of combined innovative practices in areas such as cargo handling technology routes,traffic flow organization,and yard management combining with the characteristics of the phase I project.We provide detailed explanations regarding the layout of automated and non-automated zones,the arrangement of fencing and access control systems,the path planning principles for AIV and manually operated vehicle,innovative designs for personnel and vehicle safety management within the automated zone,and future optimization directions.Ultimately,mixed operation between AIV and manually operated vehicle within the automated zone is achieved.