Because of a lack of intelligent system infrastructure during the design and construction of prefabricated high-piled wharf, this paper studies the setting of intelligent system infrastructure of prefabricated high-piled wharf.The paper summarizes the requirements of prefabricated high-piled wharf intelligent system infrastructure, analogies the setting principles of prefabricated intelligent building system, and summarizes the principles of separation of prefabricated and embedded and integrated collaborative design through project case analysis.The paper puts forward the design principles and key points of the intelligent system infrastructure of prefabricated high-piled wharf, improves the design level and construction quality of the intelligent system of prefabricated high-piled wharf, and promotes the development of the all-professional integration technology of prefabricated high-piled wharf.