This paper simulates the waves induced by the typhoon ‘Muifa’. With the driven wind conditions generated by incorporating the Jelenskin typhoon model and QSCAT/NCEP bended wind, a typhoon wave model along Jiangsu coast is developed based on the MIKE21 spectral wave model, and a comparative analysis of simulation results with and without the effect of tidal water level is conducted. The results show that, the simulation model used in this paper can reasonably reproduce the features of entire process in the development of typhoon waves, and the accuracy of typhoon waves can be improved by considering the change of tidal water level.