The bridge axis of Donghai bridge is 31 km and PHC piles are used in the pile foundation of offshore piers. Because this project is far away from the seashore without shield, the construct condition is hostile with strong wind, high wave and rapid flow. Moreover, the geologic structure there is complicated and the salt content of seawater is high, and there is only 174 operational days within a year. Therefore, the key point for the construction of this project is the construction of the large-diameter PHC pile which is adaptable to the natural conditions of such sea area. This paper introduces some key construction techniques applied to PHC piles for offshore piers of Donghai bridge, such as selection of pile type, anti-corrosion technology, selection of pile shoe, settleability analysis, water-hammer response and countermeasures to wave-current effect.