The determination of the layout plan for the hub cascade is an important prerequisite for cross water system connectivity development projects.By conducting a comprehensive comparison and selection of different cascade layout schemes for navigation hubs,taking into account factors such as navigation efficiency,water supply,irrigation,flood control,ecology,and land acquisition and resettlement,a differential economic analysis of engineering investment and operation costs is conducted to further improve the technical and economic efficiency of the project and the comprehensive utilization of water resources.The research case proposes a comparative method for the demonstration and selection of cascade layout schemes for water system connectivity engineering hubs mainly based on shipping,which can provide reference for similar projects.