The main hoist of Goupitan ship lift involves large drum，complex stress and boundary conditions，and frequent operations.The stress of the drum periodically changes，which may cause fatigue damage to the drum welds.So the fatigue strength analysis of the welds is an inseparable part of the drum design.Based on the complexity of the structure and load of the drum，this study uses the finite element analysis method to calculate the stress variation range of the drum.The modeling method fully considers the mechanical assembly characteristics of the drum group，bearing seat，and substructures of the drum group.At the same time，the study designs the weld fatigue strength by the standard “Eurocode 3” fatigue strength evaluation method.The design method of weld fatigue strength based on finite element analysis and “Eurocode 3” fatigue strength evaluation can provide references for the design of ship lift in hydro-junction.