With the vigorous development of intelligent water transportation，the monitoring of operation safety and health of high piled wharf structure based on life cycle has attracted more and more attention. Combining with a new wharf project of a port area，this paper carries out the research on the life-cycle health monitoring system of high piled wharf. Based on the structural load conditions，operating environment and monitoring instrument characteristics of high piled wharf，this paper carries out the life-cycle sensor and its durability design，line protection and replacement reservation design，develops the corresponding monitoring system，and analyzes the obtained monitoring data combining with data normalization，dynamic time warping and numerical modeling methods. The results show that the adopted data processing method can better quantify the similarity between data of different measuring points，and the real-time monitoring data can be used to evaluate the existing state of the wharf structure，which can provide a basis for the decision-making of the repair，maintenance and management of the wharf structure.