The elevation of the bridge deck at the island-bridge joint of the Hong Kong-Zhuhai-Macao Bridge is relatively low，thus the wave has a complex and strong effect on the bridge deck，artificial island and other structures at the joint of the island bridge under the design water level and wave conditions. The wave force of the island-bridge joint structure is experimentally studied through the 3D physical model tests. The results show that：1）Under the design water level and wave conditions，for the island-bridge junction，the maximum dimensionless wave horizontal force of the single-span box girder structure is 0.7 F/（ρgA2H1%）and the maximum dimensionless wave uplift force is 0.2 F/（ρgA1H1%）. 2）The wave force is larger under the action of the S（positive 0°）and SSW（22.5°）direction waves than results in other directions. 3）As the water level rises and the relative elevation becomes smaller，the wave uplift force and the horizontal force on the structure both increase. 4）The maximum dimensionless uplift wave pressure is 2.0p/（ρgH1%）and the maximum dimensionless horizontal pressure is 1.9p/（ρgH1%）.