To solve poor deceleration function and poor ecological effect of conventional ecological slope protection structure，based on the three-dimensional energy dissipation thought and pore theory of ecological environment preservation，a new ecological slope protection structure，three-dimensional reticulation slope protection structure，are developed. Through generalized flume experiment，the stability of ceramsite concrete and plain concrete under action of wave current coupling are studied，and relevant measures to enhance the structure stability are proposed. The new slope protection structure could be used in the channel regulation and slope protection engineering in the middle and lower Yangtze River and tidal reach，which provides new materials for the channel regulation theory，and would promote the technological innovation and ecological technological progress of channel regulation.