The most suitable type of protection for the bank slope of the deep groove in the Yangtze River in complex flow regimes is rock throwing. However，due to the depletion of the source of block stones，it is urgent to find a suitable protective material. Based on the existing engineering practice in the Nanjing section of the Yangtze River，sandbags are used for the first time to protect the deep groove slope of the Yangtze River in the complex flow ingress. This study introduces the structural section，sandbag body type，filling，geotextile and other relevant design conditions of the deep groove slope protection project on the right edge of the head of Nanjing Baguazhou in the Yangtze River. This paper analyzes and studied the key issues of how to ensure the accurate location of sandbag drop points. This study adopts the solution measures such as preferred construction ship，reasonable layered partition，production test，secondary positioning method，dynamic measurement correction，and increasing the detection frequency to ensure the quality of the project and provided the basis for similar projects.