Aiming at the design of a liquefied natural gas（LNG） high-pile wharf structure on the shore of the Mediterranean Sea，in order to gain the vibration amplitude，vibration frequency and cyclic numbers of the tie-in point of LNG pipeline on the structure under seismic excitation to provide the necessary data for the design of LNG pipeline，we carry out the non-linear time history analysis for the structure. Based on the widely-recognized code，we discuss the specific process of non-linear time-history analysis，such as defining the level of seismic resistance，obtaining the seismic excitation curve and matching the target spectrum，simulating the nonlinear material behavior and soil-structure interaction and setting the plastic hinge. The results show that the displacement of the tie-in point of LNG pipeline under seismic condition can satisfy the requirements of operating basis earthquake and safe shutdown earthquake.