Based on the analysis of Anhui Wangdong Yangtze River bridge in the Dongliu and the basis of the conditions of the river channel, from the point of view of the navigation, this paper proposes the navigation clearance dimensions calculation of Anhui Wangdong Yangtze River bridge, analyzes the navigation layout. Combining with the channel condition, the arrangement for the bridge pier optimizationd is analyzed. According to the bridge area waterway’s condition, and in view of the existing problems of bridge type scheme, this paper analyzes the pier layout’s optimization. The optimized bridge type scheme (78 m+228 m+638 m+228 m+78 m ) can make full use of the effective navigable water, and adapt well to the channel condition, thus the bridge type scheme recommended is reasonable and feasible.