Till now there isn’t an accurate theoretical method to determine the rotation center of the embedded large-diameter cylinder. Using infinite difference software to simulate the overturning of the cylinder under horizontal loads, we get the rotation center by analysis the model position before and after rotation. Based on the analysis of the change pattern of the rotation center with different parameters and through the comparison with the existed method named Hansen, we can get the conclusion that the new method can perfectly reflect the trend of the development of the rotation center under different parameters, thus it’s much more practical than Hansen.