In view of the problems of unreasonable transportation structure and high logistics cost in Yunnan Province,focusing on the Jinsha River-Yangtze River,Lancang River-Mekong River,and You River-Pearl River water transport channels,this paper researches on the multimodal transportation routes in the direction of Kunming to Shanghai,Kunming to Vientiane,Kunming to Guangzhou and Kunming to Qinzhou to calculate the cost of highway,railway and “highway-railway-waterway” multimodal transportation.Meanwhile,it compares economic analysis and selects advantageous routes,and puts forward suggestions from the aspects of infrastructure construction,financial support and policy guidance.The results show that,relying on the three major channels to carry out multimodal transport,the route is feasible.Under the advantageous route,the transport costs of the four groups of starting and ending points are 15.3%,31.6%,18.8% and 31.7% of highway transport,and 50.9%,86.0%,55.5% and 91.0% of railway transport,respectively,which has obvious economic advantages.It is of great significance to promote Yunnan water transportation project construction,transportation transformation and logistics cost reduction and efficiency increase.