Based on a wharf project in Shaoguan within Karst regions,we study the problem of pile foundation design and Karst caves treatment in wharf project to achieve the aim of improving the reliability and safety of pile foundation design under complex geological conditions.By combining drilling and various geophysical detection methods(including tube wave detection and elastic wave CT methods),we carry out a comprehensive survey of geological characteristics of Karst area,and propose a treatment approach involving “layered stone filling followed by grouting” for areas with weaker physical and mechanical properties of Karst caves.The results show that the distribution of Karst caves is irregular with varying greatly in size and depth.Static load test results are validated the effectiveness of this treatment approach.