In response to of the dual problems of navigation and flood control in the middle reaches of the Yangtze River,this paper analyzes the characteristics of waterway regulation in the middle reaches of the Yangtze River.Based on flow continuity equations and motion equations of water flow,the paper deduces and analyzes the impact of traditional waterway adjustment measures and guardian measures on water depth and water level.A new method of waterway regulation measure that combines adjustment,guardian and dredging measures is proposed,and its impact on navigation and flood control is calculated and analyzed.The results show that,compared to traditional measures,the water depth of the navigation channel increases significantly,while the water level decreases significantly by using the new measure,which is beneficial for the coordination of flood control and navigation.