Based on the comprehensive wharf project of Suntuan operation area in Huaibei Port area，Anhui Province，we carry out the on-site test and parameter optimization research on large diameter prestressed high-intensity concrete (PHC) pipe pile sinking for high-pile wharf in inland rivers.After obtaining the parameters of pile sinking through the initial geological survey report，we carry out the feasibility analysis of pile sinking and the improvement of construction planning，conduct trial pile sinking，high and low strain and static load tests，and optimize pile foundation design parameters based on the test results.The results indicate that the feasibility of the construction process，pile sinking equipment，pile sinking control parameters，and stopping hammer standards for large-diameter PHC pipe piles of high-pile wharf in inland rivers are verified by the depth of the pile tip entering the bearing layer and the final penetration results in the comprehensive pile sinking on-site test.The adjustment coefficient range for the ultimate lateral friction resistance standard value and ultimate pile end resistance standard value for unit area of large-diameter PHC pipe piles of high-pile wharf in inland rivers is determined by 5% to 10%.The ⑦ layer of fine sand as the bearing layer of the pile foundation is proposed，and the pile foundation parameters are synchronously optimized.