To explore the ship motion response and mooring cable force of rock drill sliding on deck barge track，the 3 850 DWT deck barge is taken as the research object.AQWA module of hydrodynamic analysis software ANSYS is applied to analyze three drilling conditions of rock drill at the front，middle and back ends of track，and to compare the differences between barge motion response and mooring cable force.The results show that the pitch and roll of barge will change obviously when the rock drill is drilled at different positions on the ship.In addition，the different displacement caused by different oil and water has a certain effect on the barge’s rolling and pitching response，and the mooring cable force of barge has little change under different working conditions.The research results can provide some reference and guidance for the evaluation，selection and countermeasures of large equipment operating on deck barges.