The general layout of the new Jianghaihe ship lock is restricted by external construction conditions.To this end，we summarize the general layout principles of ship lock.Meanwhile，we study various factors such as the construction conditions around the lock site，river channel conditions，ship navigation conditions，influence on the external environment，construction conditions，and project investment.In addition，we adopt the method of combining quantitative and qualitative analysis.As a result，the optimal lock site scheme is obtained.We also obtain the optimized layout scheme by analyzing the maximum navigable diversion flow and annual operating hours of the ship lock in the upstream entrance area and adopting methods to reduce the maximum navigation flow and sacrifice a small amount of navigation time.The results show that the general layout of ship lock should be determined by comprehensive comparison and analysis in combination with various factors.The layout can be optimized by reducing the maximum navigable flow to provide references for similar projects.