Longxu Waterway is a natural river under the hub dam.In view of the channel regulation and construction problems under the environment of large-density navigation of multi-line locks，this paper studies the construction layout scheme.Through the analysis of riverbed hydrology，navigation environment，shipping conditions，and channel regulation design scheme，the paper uses mathematical and physical models and concludes that large-density ship navigation，bridge navigation restrictions，and construction precipitation are three difficult points in the construction layout of Longxu Waterway regulation.Therefore，the paper formulates the construction layout principles of “widening the channel，half-section layered construction，half-section navigation，and navigation traffic control” to alleviate the contradiction between construction and navigation and ensure the smooth progress of construction and the safety of ship navigation.The research ideas can be used as a reference for similar projects.