Taking Shanghai LNG pipeline project，the major crossing project of the Yangtze Estuary，as an example，the paper studies the interaction between the crossing project and the planned regulation buildings in the Yangtze Estuary and the relevant engineering measures.Shanghai LNG pipeline project intersects with the planned Ruifengsha regulation project and the Baozhen beach protection project，the tunnel construction will have a certain impact on each other.To fully consider the above impacts，prepare the corresponding safety protection，and ensure that the implementation of the planned project will not be affected，it is necessary to carry out a special study on the impact of the project on the planned renovation buildings of the North South Port and the measures to solve it.This paper uses the mature η-ζ method to calculate the internal force of the tunnel structure.The results show that the deformation of the LNG pipeline project will exceed the control standard when the planned Ruifengsha regulation project and Baozhen beach protection project implement，and corresponding protective measures should be taken.It also shows that the short-term plan can eliminate the impact of the beach protection project in the planned Baozhen Town on the tunnel line A，but not the impact of the planned Ruifengsha regulation project on the tunnel line B.Therefore，the long-term plan should be implemented simultaneously during the construction of the Ruifengsha regulation project.