Based on the analysis of riverbed evolution and navigation-obstructing characteristics of Qichun waterway in the middle reaches of the Yangtze River, this paper studies the effect of the project scheme for regulating the waterway with a depth of 6. 0 m by river model test and determines the regulation project scheme of Qichun waterway. The project scheme consists of a submerged dam project on the Lijiazhou beach, a project of three shoal protection belts, a high shoal protection project, and a revetment reinforcement project on the left bank. The research results show that this project scheme only affects the project area and its vicinity and has a slight impact on the overall river regime, flood control, embankments, and other external environments. The revetment reinforcement project on the left bank further enhances the stability of the shoreline on the left bank. The research provides some experience in designing channel regulation project schemes under complex external environments.