Taking Wanjiang embankment retaining wall project of Dongguan inland waterway in China Great Bay Area as an example，this paper introduces the engineering application of prestressed U-shaped sheet pile as embankment retaining wall. Firstly，the scheme comparison shows that the U-shaped sheet pile scheme has the advantages of fast construction speed，little influence on the river and low project cost. Then，the maximum applicable height of U-shaped sheet pile as cantilever retaining structure is obtained through theoretical calculation and analysis. Finally，the factors of horizontal displacement are analyzed，and the measures of presetting displacement and reinforcing the foundation behind the wall in advance are put forward to reduce the horizontal displacement. The field measured data show that the horizontal deformation mainly occurs in the first 45 days，and the later deformation is small. The operation data of retaining wall project show that the application is good，which can provide reference for similar inland waterway projects.