Pile layout is the most critical design issue for the suspended structure subjected to forces of various directions（berthing force & mooring force，etc.），for which trade-off should be made among several aspects including the axial compressive and pullout force，pile strength，structural deflection and the constructability on site. Given such constraints and forces，traditional design procedure requires plenty of time-consuming iterations while the most optimized scheme is not always accessible. Therefore，to optimize the pile layout，GA（genetic algorithm）is employed with the calculation procedure of FEM embedded. Taking the horizontal & vertical angles and location of the pile top of each pile as the decision variables，utilizing several initial pile layout patterns from engineer’s judgement as the prior knowledge，and exerting the constraint condition including the limitation of internal force and no geometric interference，the evolution of pile layout is implemented，based on which a dedicated program is developed and calculating demo of a practical case is presented.