The outbreak of COVID-19 in 2020 has had a profound impact on the development of ports in the Guangdong-Hong Kong-Macao Greater Bay Area. Based on the current development situation，it is estimated that the impact of COVID-19 on ports development in the Guangdong-Hong Kong-Macao Greater Bay Area is generally controllable，and the port development will gradually return to normal and even surpass the pre-epidemic level in the later stage. This paper also puts forward some suggestions for the port development in the post-epidemic era，including carrying out epidemic prevention and control scientifically，accelerating the construction of smart ports，and improving the collection and distribution system and extending port service functions.