Steel pipe piles are the most widely used type of piles in marine engineering. Nevertheless，steel pipe pile driving under complex stratum conditions is often difficult. By investigating an actual project，this paper presents an experimental study of the construction of steel pipe pile driving in a dense sand-bearing gravel and cobble stratum through the stratum in-situ test，pile driving model test，drivability analysis of the foundation pile，and full-scale field test. The results support the following conclusions：1）The experimental results of pile skin-soil friction resistance need proper improvement due to the use of the artificial simulated stratum for model test. 2）For a dense sand-bearing gravel and cobble stratum，a range of 0.7-1.0 is available for the blocking coefficient of the steel pipe pile tip，225 kPa is advisable for the unit friction resistance on the pile skin，and the unit resistance at the pile tip should not be less than 13 MPa. 3）Vibration and impact methods have trouble driving steel pipe piles in a dense sand-bearing gravel and cobble stratum. Consequently，achieving the designed penetration depth might require that part of the soil plugs inside the pile be removed by an appropriate method.