An experimental study on wave run-up and reflection on sloping breakwaters through a new type of artificial block TB-CUBE was conducted. It is found that the wave run-up would increase at the beginning and then decrease with the increase of breakwater slope. Additionally，the wave run-up would decrease and then increase with the increase of the water depth. Meanwhile，the reflection coefficient in front of breakwater presented a gradually shrinking trend with the elevated water depth and slope. According to the relevant factors of the wave run-up on the new type of face protection block TB-CUBE，the empirical formula of the wave run-up on the block is fitted，comparison analysis of wave run-up formula is conducted between similar formula from JTS 145—2015 Code of Hydrology for Harbour and Waterway and that from this research. For this TB-CUBE，the combined empirical formula from this study performed better than that in the specification.