The river channel of the sharp-bend compartment corridor is sharp bend and the river surface is narrow. The turning angle of the channel at the top of the curve is large，and the mainstream flow velocity at the turning section is high. To counter the problem that ships cannot pass the turning section of the corridor，we carry out a study on channel regulation at the sharp bend section. By the method of normal fixed bed physical model test and combining with the ship model test，we obtain the optimal regulation scheme which combines dredging with adjusting course based on the analysis of the indices such as the water level along the course，the velocity of the midcourse，the transverse velocity of the channel and the ship model sailing parameters. The experimental results show that，in the navigable water area with the maximum navigable flow of 2 010 m3/s，the navigable flow conditions，such as longitudinal and transverse velocity，are improved，the ship’s curved track zone is reduced，and the two-way navigable ships can pass through the sharp bend section of the corridor smoothly. This study can provide reference for the regulation of waterway in similar sharp curve sections.