Karachi Port is the largest seaport in Pakistan which is located on the southwest of Karachi City and it is the east end of the China-Pakistan Economic Corridor. The Karachi Port development is facing problems such as prominent port-city contradictions and busy transportation channels. Based on the analysis of current situation of Karachi Port transportation channels，we predict the volume of collection and distribution through Karachi City，and propose four channel options of port access road，coastal railways，coastal roads，ML-1 railways and port railways. Different combination solutions are discussed combined with Karachi Port and Karachi City development：1）port access road + ML-1 railway and port railway reconstruction；2）port access road + coastal road；3）coastal road + ML-1 railway and port railway reconstruction；4）coastal railway；5）coastal railway + coastal road. After comparing and selecting each combination option，the comprehensive solution is proposed，which may serve as reference for similar projects.