In view of the complex layout conditions of Huai’an East Ship Lock，which is restricted by the surrounding buildings already built and to be built，we carry out a comparative analysis on the lock location scheme，the double-line lock’s staggered layout and parallel layout schemes，and whether all the management areas involved in the upstream approach channel are expropriated，and obtain the location of the south gate while choosing the staggered arrangement’ of the double-line ship lock and all expropriation of the upper approach channel as the optimal scheme. It is proposed that the ship lock layout should be determined combining with the surrounding constraints，navigation conditions，navigation safety，flood control，ship lock operation and management，land acquisition，demolition and investment，etc.，and the next-stage research direction is presented. The research result may serve as reference for the ship lock arrangement under complex surrounding environment.