Daijiazhou waterway is one of the most complicated shoal segments in the 6 m-depth waterway regulation project at the Wuhan to Anqing section of the Yangtze River main line，and the difficult reach for the 6 m-depth waterway arrival to Wuhan. In view that the water depth of Daijiazhou reach is less than 6 m，we analyze the channel condition and changing trend of Daijiazhou reach under the new water and sediment conditions，and propose the regulation idea，principle and scheme. The result of the physical model experiment shows that Daijiazhou waterway can realize the construction target of 6.0 m×110 m×1 050 m after implementation of the regulation engineering，and a small amount of maintenance dredging is required in unfavorable hydrological years to achieve the 200 m channel width in the future.