Aiming at the mooring safety problem of container ship stevedoring operations，based on the three-dimensional potential flow theory，the AQWA software is used to conduct frequency domain hydrodynamic analysis and time domain coupling analysis for moored container ships. The six-degree-of-freedom response amplitude operator，time-domain motion and the maximum tension of the mooring cable under various wind，wave and current loads under different loading conditions are calculated. The effects of different loading conditions on the six-degree-of-freedom RAO and the amount of movement of the container ship are analyzed. Wharf mooring safety is assessed under stevedoring operations. The results show that：1）Different loading conditions have the greatest impact on rolling motion. 2）When fully loaded，the amount of movement of the container ship is greater than that of ballast conditions，and the mooring cable has a greater load. The test results provide a simulation analysis basis for evaluating the mooring safety of ships during stevedoring operations，and also have certain guiding value for optimizing the mooring scheme of the wharf.