Aiming at the problems of strong weathered rock geological condition，reef cover area more than 169，000 m2，limited construction space，navigable control，and blasting site only 470 m away from the nearest structure in the third phase of reef blasting construction of Meizhou Bay waterway in Fujian Province，we study the single-stage explosive quantity，vibration wave intensity，hole network layout，and tidal change. We applyφ115 mm blast hole，2.0 m×2.5 m hole network layout and inter-row millisecond blasting technology，use the tidal effect to further reduce the negative impact of blasting，and successfully complete the construction task. The results show that when the single-stage explosive quantity is not more than 300 kg，the vibration wave generated by blasting construction does not adversely affect the surrounding production and living areas，and the use of tidal water can reduce the vibration wave to a certain extent.