A good design of the pile layout of a high-piled pier can make the structure more economical and reasonable. However，the design process of pile layout usually needs a lot of manpower. In this paper，the optimization algorithm is integrated into the calculation and post-processing through the APDL command flow of Ansys software，to realize automatic optimization of pile layout under specific load conditions. The optimization process of genetic algorithm and the influence of optimization parameters on the optimization process are introduced by taking an example of optimization of pile layout，to get an optimized pile layout with small internal force value in very few time.