In view of the increasingly prominent contradiction between navigation demand and deep-water channel width resources brought by the increase of large-scale ships’ rendezvous demand in the Yangtze Estuary deep-water channel，we study the utilization standard of the natural water depth of the deep-water channel slope. Based on the principle of minimizing the impact on channel maintenance and utilizing the natural water depth，we propose the width，depth and，section of the slope’s natural water depth utilization by using the method of statistical analysis of the measured data and theoretical calculation. It provides a basis for relevant departments to carry out ship tests and research on support measures，and is fully applied to the overall scheme for the utilization of the slope’s natural water depth.