Aiming at the problem of the regulation project of estuary channel of Chaohu Lake in the Yangtze River to Huaihe River project，we adopt the software of MIKE3 to establish a three-dimensional numerical model of the wave and sediment in Chaohu Lake，and study the effects of wave characteristics and sediment movement on the sedimentation of estuary channel in Chaohu Lake combining with the on-site observation data of the lake flow，wave and sediment. We analyze the wave characteristics of Chaohu Lake and the response relationship between wind speed and wave height of Baishitian River and Mawei River estuary channel，the response relationship between effective wave height and bottom shear stress，and discuss and analyze the influence of Chaohu Lake sediment transport on the estuary channel under wave and lake flow. The results show that the wave characteristics of Chaohu Lake are closely related to its wind conditions，and the nearshore sediment mainly moves in the form of “lifting the sand by waves and transporting the sand by lake flow”，which will have a direct influence on the deposition of Chaohu Lake estuary channel.