The channel from Hengli to Likou in the middle reaches of the Dongjiang River is continuously shallowing and needs to be regulated. Meanwhile，this section undertakes the task of sand mining. To explore the feasibility of sand mining in the river reach under the background of the implementation of waterway expansion and upgrading project，the depth integral hydrodynamics numerical experiment is used to study the changes in water depth，velocity，and water surface profile of the reach after the implementation of the channel improvement plan and the sand mining plan at the same time. Thus the regulation scheme is adjusted combined with feedback information. The results show that the implementation of sand mining planning after waterway regulation will directly lead to the monotonous decline of upstream water level and the deterioration of water flow in the channel. So a new round of regulation must be carried out to meet the navigation requirements. On the whole，the 13th five-year plan for sand mining can be realized in combination with waterway regulation. However，in the future，under the premise of ensuring the waterway transportation capacity of the channel，the Dongjiang River reach has no objective condition for planing sand mining projects.