Reclamation is applied in port construction, artificial island and so on, which has the characteristics of large engineering volume, long transportation distance and high cost.In order to obtain accurate figures in reclamation sand volume calculation as far as possible, the detailed calculation method of reclamation sand volume based on multi-beam measurement data and Matlab programming is introduced.According to the foundation treatment effect of vibroflotation and drainage board, the consolidation and surcharge effects of dredger fill sand are inversely deduced, thus the amount of dredger fill sand is accurately calculated and the accurate handover elevation of reclamation fill is given.In the practice of Panama Amador cruise terminal project, the amount of reclamation accurately calculated can save about 70, 000 m3 compared with the traditional calculation method.