The cylinder array is a common marine engineering structure，but in reality，ocean waves are usually multi-directional irregular waves.It is of great significance to study the effect of wave directional distribution on the interaction of wave on an array of large scale cylinders.Linton and Evans’ method about wave-cylinders interaction is used as the transfer function，which is combined with the multi-directional random waves to predict the wave loads on array of cylinders.The numerical calculation results are verified by the results of the physical experiment.Wave forces and the group coefficients for two cylinders in tandem and parallel layout are calculated.The results indicate that the wave directionality has great effects on the wave force and the group coefficients，especially to the transverse wave force.