Hong Kong-Zhuhai-Macau Bridge project is the deepest buried depth of immersed tunnel in the open sea.The tubes in this project have large cross sections,heavy weight,and high standard of crack resistance of concrete.It is the first one using industrial prefabricated immersed tubes for tunnel construction in China.Due to complexities of the prefabrication technology,deep studies were made to develop various improvements and innovations.This paper mainly outlines the industrial prefabrication technology and its application.