Mid-span deflection is widely spreaded in prestressed concrete bridges,and the root cause is that the bridge structure in the construction process accumulated unbalanced moment.In order to fundamentally solve the problem,and reduce the unbalanced moment,based on zero bending moment of dead load theory,this paper studies the arrangement of tendon with beeline and curve in concrete bridges and deduces relevant calculation formulas of prestressing tendon layout.The method of prestressing tendon layout is established and verified to be effective by examples,and the mid-span deformation of prestressed concrete bridges is controlled initiatively.