In recent years,the left-branch of Anqing river course tends wider and shallower because of the development of its mid-branch,thereby it causes the obstruction of navigation.This paper analyzes the causes of navigation obstruction and demonstrates the regulation schemes based on the river model experiment.After implementation of the phaseⅠ project during 2010 and 2011,the navigation condition is improved obviously and the waterway keeps smooth in the dry season.Preliminary regulation effect has been achieved.