Based on the successfully predicted Majiazui waterway riverbed evolution trend using the prototype observation data analysis and model test method,the paper studies the channel regulation measures,and puts forward the principle and contents.After the project,Nanxingzhou right branch channel was scoured,the channel slot and left branch deposited,the left branch diversion ratio decreased,and the channel condition was improved significantly and thus met the channel’s planned scale.The successful experience may serve as reference for the middle and lower reaches of the Yangtze River waterway regulation.