The overall length of the Hong Kong-Zhuhai-Macao bridge immersed tunnel is 6 km.The channel tunnel arranges through “W” shape along the longitudinal position.It exists that the ventilation technology of the tunnel with long distance is difficult.The ventilation technology of the immersed tunnel with long distance between the ventilation for alone head and the ventilation in fan series is researched.Based on the technical design of ventilation，fan selection，economic contrast，etc.,we expound the advantages of the ventilation for single head，which may serve as reference for the ventilation of tunnel with long distance.