There are three channels which can be navigation paths in Fujiangsha river reach.However，they all don’t meet the scale requirement of 12.5 m deep waterway，so this river reach shall be regulated，and the selection of the channel as a navigable path is the primary task.In this research，effectiveness and impact of regulation in each channel is studied by means of tidal current and sediment physical model experiment.Based on the experiment，preliminary choice of the navigation path can be determined.The movable bed experiment shows that the south channel of Fujiangsha waterway can maintain 12.5 m deep after regulation，but one-way traffic is still hard to be satisfied and the effect in the entrance and middle of the channel is poorer.It’s difficult to realize two-way traffic in the north channel of Fujiangsha waterway because this channel is restricted by the cross-section of Rugao middle channel and there are too many navigation-impeding sections in this channel.So one-way traffic can be considered in the north channel at present.As to the middle channel of Fujiangsha waterway，the difficulty of regulation is relatively small because this channel is at the development stage now and the regulation has less effect on the surrounding environment.