The port contribution to regional economy is studied in view of the economic and social development as well as resource utilization in line with the international practice on theoretical methods, calculation models and indicators. Firstly, the port-centered economic activities are widely investigated and prudently identified. Subsequently, the evaluation index system of port economic contribution is established. And then, an optimized calculation method is explored, which integrates the input-output model applied internationally with the particular condition in China. Thus, it is probable to acquire a comparatively scientific, comprehensive and objective evaluation of the port contribution to the city and the region.