OD flow simulation model constructed in the paper consists of container transport OD flow network in the Pearl River Delta, fuzzy synthesis assess model for port evaluation, and Logit model for the transshipment port selection. The paper applies the models to simulate and calculate the container transport demand in different OD flow paths based on the container generating volume forecast in the Pearl River Delta in 2020 and forecasts the annual throughput of container ports in the Pearl River Delta, so as to provide a guidance for the rational layout planning for container ports in the Pearl River Delta in 2020.