Based on a comprehensive analysis including case analysis , theoretical analysis, river regime analysis and tidal current mathematical model research, regulation parameters such as water level, bending rate and river widening rate are determined. In the service of existing channel plan objectives and channel function positioning, we research the phased regulation scheme and regulation line of the Yangtze River estuary waterway regulation project, which may guide the waterway construction during the planning period. The research results play a supporting role on the compilation of Waterway Ddevelopment Plan for the Yangtze Estuary.