Selecting a structural segment of high-pile wharf in Zhanjiang as the research data, we build a space finite element model by finite element software ANSYS. Considering four kinds of horizontal loading effects as controlled working conditions, we calculate and analyze the internal force of pier pile under different fork pile fastened angles, and discuss the influence of horizontal earthquake effect and ship load on the laying of fork pile fastened angle. The results indicate that: when the fastened angle is growing bigger, the lateral displacement and bending moment of such structure increase, but the longitudinal displacement and bending moment become smaller. The displacement and the bending moment get the maximum under the working condition of the longitudinal horizontal earthquake effect. When the effect of longitudinal and lateral controlled working conditions is considered, fork pile fastened angle 20° will be reasonable in the structural segment of such high-pile wharf.