This paper introduces the design scheme of waterway layout and navigational aids for Hong Kong-Zhuhai-Macao Bridge. It is proposed to establish an integrated 3D network system of navigational aids along the bridge waters by combining the use of buoys and bridge navigational marks, visual beacons and radio ones, as well as by establishing the telemetering and remote control system for aids to navigation, with the aim of providing allweather navigation aid service and ensuring the safety of both navigation ships and the bridge.